Disorders of Motility Paper

Disorders of Motility Paper
Gastric Acid Stimulation and Production

The corrosive substance that is made up of the pepsin and the gastric acid is secreted in the gastric mucosa. The chemoreceptors stimulate the gastric mucosal cells. The chemoreceptors act in a two-way tract because it can either inhibit or stimulate the release of gastric acid and pepsin into the stomach.

In the gastric walls, there exist some mucous that protect the gastric mucosa and the walls against corrosion that causes harm to the gastric mucosa. The mucous also helps the corroded gastric mucosa and walls to repair itself before further damage that leads to gastritis and ulcers.  According to (Kao, Sheu & Wu, 2016). Gastric acid is useful in the body because it destroys the disease-causing microorganism and allows for the assimilation of proteins and the ingestion of calcium, iron, vitamin B12and medication. Gastric acid, by bringing down pH, slaughters ingested microorganisms and cutoff points bacterial development in the stomach and avoids intestinal diseases, for example, Clostridium difficile. Besides, gastric acid may have a part in forestalling unconstrained bacterial peritonitis.

Changes that occur in GERD, PUD, and Gastritis

The components acknowledged as imperative for the improvement of Gastroesophageal Reflux Disease (GERD) have been well documented. Abnormality of any of these elements holds the possibility to exasperate the typical harmony. Kao, Sheu & Wu, (2016) Argues that elements incorporate gastric acid among other refluxed substance; deferred gastric discharging. Besides, auxiliary and physiologic antireflux instruments at the gastroesophageal locale; transient lower esophageal sphincter unwinding (TLESR); esophageal freedom systems; ingested aggravations; ingested substances that adjust gastric, bring down esophageal sphincter (LES), or esophageal engine work; mucosal trustworthiness and protection components; instinctive extreme touchiness; and hereditary variables.

Factors selected

Age is one of the factors that influence the diagnosis and treatment of the disorders of motility. Children, infants, and the elderly suffer the most from the diseases of motility compared to the young people and those who are in middle adulthood. It is challenging to diagnose the disorders among the infants, children, and the elderly because the disorders present itself just like any other gastrointestinal disorders (Jean & Robert, 2014). Besides, in the management of the diseases, it is critical to identify the type of the medication that applies the best for the patient and the dosage needs to be adjusted for the age group primarily for the elderly, children and infants to avoid adverse drug interaction and toxicity.

People who have stress-related to other health problems such as those that require treatment in the intensive care unit or have been diagnosed with terminal diseases increases the chances of an individual to acquires disorders of gastrointestinal motility. According to (Orlando, 2018) dietary factors and the personal behaviors such as taking meals later or going without food for almost all day, increases the direct action of the gastric acid on the gastric mucosa, causing irritation which in the later processes leads to gastric ulcers.

Smoking and taking alcohol is another factor that affects the pathophysiology of the motility disorders of the gastro intestine. Chronic alcohol intake disturbs the gastric mucosal barrier that reduces the production of the cytoprotective prostaglandins (Orlando, 2018). Smoking, on the other hand, causes the reduction of circulating epidermal growth factors and increases the production of gastric acid that causes corrosion of gastric mucosa, thus gastritis, PUD, and GERD.

Diagnosis and Treatment

A disorder of gastric motility ought to be identified in individuals with constant regurgitation. Imaging studies are utilized to affirm postponed gastric purging; the most widely recognized type of a gastric motility issue. Different reasons for unending regurgitating, for instance, metabolic or endocrine problem, another stomach issue, mechanical reasons for the gastric check, and lower gastrointestinal tract illness, are then precluded (Santacrose, 2017). In the event that no fundamental cause is resolved, a pragmatic issue of gastric exhausting is hypothetically analyzed. Treatment comprises of dietary administration and gastric pro-kinetic specialists. Cisapride is the medication of decision for treating deferred gastric purging took after by erythromycin and ranitidine or nizatidine.

Since a few distinct medications can bring about intestinal motility issue, evading them, if conceivable, may resolve the condition. In some patients, pharmacotherapy might be useful. Gastric pre-prandial dysrhythmia may prompt hindered gastric discharging, hence adding to sporadic retention of medications from the small digestive tract and conducing to impairing reaction changes of the treatment. Psychological petitions, for instance, individual behavioral therapy, hypnotherapy have been fruitful in overseeing stomach torment in patients with the bad-tempered inside disorder; in any case, they have restricted utility for routine use in day by day work on attributable to their work seriousness and fast accessibility. According to ((Santacrose, 2017) surgery is not always performed to treat patients with essential intestinal motility issue, aside from in the treatment of idiopathic clogging that does not react to therapeutic procedures and in the treatment of intestinal pseudo-deterrent. Surgery for these patients is always palliative. Just patients who are weakened by their indications or those whose nourishing status is antagonistically influenced experience surgery.

Neural undifferentiated organism transplantation might be helpful for patients with intestinal motility issue related to enteric neuropathy (Jean & Robert, 2014). A murine review showed that transplanted enteric neural ancestor cells could create functional enteric neurons in the postnatal inside. Patients with intestinal motility issue must be taught different methods to help them adapt to their condition. Besides, they are also educated to stay away from any circumstance or substance that may make the side effects decline. Mental guiding might be useful.

Gastritis Mind Map


Kao, C. Y., Sheu, B. S., & Wu, J. J. (2016). Helicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis. Biomedical Journal, 39(1), 14-23.

Santacrose, L. (2017). Intestinal motility disorders treatment and management. Medscape. Retrieved April 24, 2017, from http://emedicine.medscape.com/article/179937-treatment

Orlando, R. C. (2018). Pathophysiology of gastroesophageal reflux disease. Journal of clinical gastroenterology42(5), 584-588.

Jean, A. H., & Robert, J. W. (2014). Diagnosis and treatment of gastric motility disorders. Veterinary Clinics of North America: Small Animal Practice29(2), 377-395.