Pathopharmacological Foundations for Advanced Nursing Practice – C155

Pathopharmacological Foundations for Advanced Nursing Practice – C155
A1. Pathophysiology – A. Investigate one of the following disease processes: asthma.

1. Analyze the pathophysiology of the disease process you selected in part A.
Pathophysiology should transition from cellular level (smooth muscle cells) to systems level (pulmonary, cardiovascular, etc).
Here is an outline example of the elements to address in this section:
Introduction paragraph for the section – in general describe asthma including prevalence, risk factors and comorbidities
Second paragraph – cellular changes in the respiratory system (inflammatory cascade, mast cell release/histamine release). Smooth muscle constricts, inflammation causes edema and erythema of bronchiole smooth muscle cells, inflammation causes leaky capillaries releasing serum containing white blood cells, etc. Also discuss the decreased ability to exchange oxygen/carbon dioxide due to smooth muscle constriction and inflammatory process.
Third paragraph – Changes in the lung as a whole, and other organs that might compensate or be affected (heart, nervous system)
Fourth paragraph – Body as a whole, how a patient might compensate (tri-podding, tachypnea, etc. ).
Fifth paragraph – Distinguish the difference between intermittent and persistent asthma.
Conclusion paragraph– Set up this paragraph to transition to the next section. Suggest that management of asthma is largely preventative practices (avoidance of triggers and compliant use of prophylactic medications), and correct use of medication to control symptoms.


2. Discuss the standard of practice for the selected disease process.

a. Discuss the evidence-based pharmacological treatments in your state and how they affect management of the selected disease in your community. – Florida

b. Discuss clinical guidelines for assessment, diagnosis, and patient education for the selected disease process.
c. Compare the standard practice for managing the disease within your community with state or national practices. – Florida
3. Discuss characteristics of and resources for a patient who manages the selected disease well, including access to care, treatment options, life expectancy, and outcomes.

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