1395765

Question: Cholesterol homeostasis involves:
control of amount of HMGCoA reductase present– rates of
synthes…


Cholesterol homeostasis involves:

control of amount of HMGCoA reductase present– rates of
synthesis and breakdown

covalent modification of HMGCoA reductase–
inactivated by phosphorylation

allosteric control of HMGCoA reductase activity
– negative feedback by cholesterol and derivatives of
mevalonate

control of expression of LDL receptors
– in response to cellular demand for cholesterol

synthesis of bile acids
– stimulated by increased liver [cholesterol]

Q1. Which of the above are potential therapeutic
targets?

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