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Question: 1. (Chapter 12 and 13) Most human obesity does not follow Mendelian in patterns environmental var…



1. (Chapter 12 and 13) Most human obesity does not follow Mendelian in patterns environmental variables. Insights into how specific genes function content have come from studies of mutant, obese mice. In one mutant s obesity is inherited as a recessive trait. A comparison of the DNA sequence o and tub alleles has revealed a single base-pair change: G-C base pair has been mutated to a T-A base pair. The mutation causes an al the initial 5 base of the first intron. Therefore, in the homozygous tubltub mut longer transcript is found. Propose a molecularly based explanation for how a single base change causes a nonfunctional gene product to be produced, why a longer transcript is found in tubltub mutants, and why the tub mutant is recessive . because body fat content is determined by a number of interacting genes and to regulate body fat f the tub Within the transcribed region, a ant, a

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1. (Chapter 12 and 13) Most human obesity does not follow Mendelian in patterns environmental variables. Insights into how specific genes function content have come from studies of mutant, obese mice. In one mutant s obesity is inherited as a recessive trait. A comparison of the DNA sequence o and tub alleles has revealed a single base-pair change: G-C base pair has been mutated to a T-A base pair. The mutation causes an al the initial 5' base of the first intron. Therefore, in the homozygous tubltub mut longer transcript is found. Propose a molecularly based explanation for how a single base change causes a nonfunctional gene product to be produced, why a longer transcript is found in tubltub mutants, and why the tub mutant is recessive . because body fat content is determined by a number of interacting genes and to regulate body fat f the tub Within the transcribed region, a ant, a

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