1395535

Question: Assume ionic concentrations in the nervous system
of:
[K]o = 4 mM
[K]i= 155
mM
[Na]o= 145 mM
[Na]…


Assume ionic concentrations in the nervous system
of:

[K]o = 4 mM

[K]i= 155
mM

[Na]o= 145 mM

[Na]i= 12 mM

7. Use the GHK equation (ignoring any contribution by Cl
or the Na/K pump), and assume RT / zF = 58 mV, to calculate the RMP
of a cell when the gK to gNa ratio is:

i) 10:1?

ii) 50:1?   

iii) 100:1?

8. Which of the above permeability ratios most closely
represents the membrane of a neuron at rest (assuming a cell at
rest has an RMP of -70 mV)? Why? [2]

9. Which of the above permeability ratios most closely
represents the membrane of a glia cell at rest? Why?
[2]

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